Table 5. Reported mortality of unstable angina


Letter in   Primary         Definition   Patients   Study              Deaths/100
Figure 2    study           for entry    entered    interval           patients/month
____________________________________________________________________________________
    A       Clinical        EMT           1,427     Prehospital,            4.2
            trial:          diagnoses               presenting
            lidocaine       of                      to
            vs.             possible                paramedics
            placebo         acute MI

    B       Multicenter     Increasing    3,465     Presenting              2.6
            Chest           New onset               at ED
            Pain
            Trial
                                            458     Postdischarge           1.0
                                                    to
                                                    approximately
                                                    2.3 years

    C       Natural         Increasing    4,698     Presenting              5.0
            history                                 at ED
            of
            angina                                  ICU                     0.2
            patients                                discharge
                                                    to 1 year

    D       Clinical        Increasing      484     First 3                 2.0
            trial:          ECG                     days of
            aspirin         changes                 ICU
            vs.                                     admission
            heparin

    E       Clinical        Rest            133     ICU                     6.0
            trial:          Increasing              admission
            nifedipine                              to 2
                                                    weeks
            vs.                                     2 weeks                 0.4
            propranolol                             post-
            plus                                    admission
            nitrate                                 to 6
                                                    months

    F       Reaction        Increasing      403     Day 7-11                1.6
            to              New onset               of ICU
            discontinuing   ECG                     admission
            heparin         changes

    G       Prognostic      Rest            911     ICU                     0.2
            significance    Increasing              admission
            of ECG          New onset               to 1 year

    H       Clinical        Increasing      100     Discharge               4.8
            trial:          New onset               to 1
            propranolol     ECG                     month
            vs.             changes                 post-
            diltiazem                               presentation

    I       Outcome         Rest            196     Discharge               0.75
            of              Increasing              to 4
            unstable                                months
            angina

    J       Describe        Rest          4,698     ICU                     0.5
            events          Increasing              discharge
            for ICU         No enzymes              to 1 year
            patients

    K       Smoking         None            157     Months                  1.0
            outcomes                                2-6
                                                    postpresentation

    L       Clinical        Ejection      6,797     Screening               0.5
            trial:          fraction                to
            Enalapril       <35%                    average
            vs.                                     of 40
            placebo                                 months

    M       Clinical        Age >60       5,736     Screening               0.06
            trial:          SBP >160                to
            Antihyper-      DBP <90                 average
            tensives                                of 4.5
            vs.                                     years
            placebo

Key = A: Hargarten, Aprahamian, Stueven et al., 1986;B: White,
Lee, Cook et.al., 1990; C: Karlson, Herlitz, Pettersson et al.,
1993; D: Theroux, Waters, Qiu et al., 1993; E: Muller, Turi,
Pearle et al., 1984; F: Theroux, Waters, Lam et al., 1992; G:
Nyman, Areskog, Areskog et al., 1993; H: Theroux, Taeymans,
Morissette et al., 1985; I: Wilcox, Freedman, McCredie et al.,
1989; J: Cairns, Singer, Gent et al., 1989; K: Daly, Mulcahy
Graham et al., 1983. L: Yusef, Pepine, Garces et al., 1992; M:
SHEP Cooperative Research Group, 1991.